Comparative transcriptomics reveals different profiles between diflubenzuron-resistant and -susceptible phenotypes of the mosquito Culex pipiens

Abstract

Chitin-synthesis inhibitors (CSIs) represent a major tool in vector control. The intensive use of these compounds has led to the evolution of resistance against several CSIs, including diflubenzuron (DFB). DFB resistance has been associated to a target-site mechanism; however, studies investigating the gene expression profile of resistant phenotypes are limited, preventing a full understanding of DFB resistance. Here, we analyzed the constitutive gene expression of susceptible and DFB-resistant individuals of the mosquito Culex pipiens, a major disease vector in temperate areas.