Association of electrocardiogram features with risk of obstructed sleep apnea: a population-based cohort study.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Sleep and Breathing Pub Date : 2025-02-11 DOI:10.1007/s11325-025-03266-7

Chuchu Wu, Jun Huang, Minjing Huang, Yiting Tan, Chuanjiang Chen, Murui Zheng, Wenjing Zhao, Yangjie Xu, Lili Guo, Xiuyi Wu, Yumei Xue, Hai Deng, Xudong Liu

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引用次数: 0

Abstract

Background: There is limited investigation on the longitudinal association between common electrocardiogram (ECG) features and the incidence of obstructive sleep apnea (OSA). This study aimed to examine the association of common ECG features with the incidence of OSA in a prospective cohort.

Methods: 2,563 participants aged 60 years or more were selected from the baseline survey of the Guangzhou Heart Study. OSA was evaluated by the Berlin Questionnaire. Eight electrocardiogram features including PR interval, QRS duration, QT interval, QTc interval, heart rate, P-wave, R-wave, and T-wave were extracted from 24-hour single-lead Holter. Relative risk (RR) with 95% confidence interval (CI) was estimated using the multivariate logistic regression model. A receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive ability of ECG features.

Results: 397 (15.5%) participants were divided into the OSA group and 2,166 (84.5%) into the OSA non-group. When comparing the highest with the lowest quartiles, heart rate was related to a 30% reduced risk of OSA (RR: 0.70, 95%CI: 0.51-0.97) after adjustment for possible confounders. Participants with prolonged PR interval were more likely to be at risk of OSA (RR: 2.68, 95%CI: 1.02-6.55). No significant association was found between the other six ECG features and OSA risk. Area under ROC curve was 0.676 (95% CI: 0.648-0.704), 0.676 (95%CI: 0.648-0.704), and 0.678 (95%CI: 0.651-0.706) for heart rate, PR interval, and their combination, respectively.

Conclusions: The results suggest that heart rate and PR interval are related to OSA incidence. Future studies should be carried out in different populations, and consider the use of portable monitors together with scales to comprehensively determine OSA, and comprehensively elucidate the relationship of various ECG features and their changes with OSA occurrence.

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.