Irina Yu Ponedel'kina, Elvira A Khaybrakhmanova, Lyubov Yu Rakhimova
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Abstract
Zinc hyaluronate (HA-Zn) is a polymeric salt that combines the unique properties of natural hyaluronic acid (HA) and such a vital element as zinc, which has antimicrobial, antiviral, antifungal, and antioxidant properties. For therapeutic purposes, the HA-Zn substance (in various formulations) is used mainly in contact with biological surfaces, including mucous membranes, and increased mucoadhesiveness can provide prolonged local action of this substance. Using porcine stomach mucin (type III) and turbidimetric titration at pH 2.0, 4.0, 6.5 and 8.0, this study was aimed to evaluate the mucoadhesiveness of HA-Zn at low concentrations in aqueous solutions (0.1-1.0 mg/mL). For comparison, the HA sodium salt (HA-Na) mucoadhesiveness was tested. The results showed that HA-Zn, unlike HA-Na, exhibited mucoadhesive properties at all pH values, and the strongest mucoadhesiveness was observed under acidic conditions at the HA-Zn concentration of ≥0.78 mg/mL and HA-Zn/mucin weight ratios of 1.0-1.1 and higher.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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