Antoine Eskander, Rinku Sutradhar, Elie Isenberg-Grzeda, Rui Fu, Alyson Mahar, Simone N Vigod, James Bolton, Julie Deleemans, Wing C Chan, Natalie G Coburn, Julie Hallet
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引用次数: 0
Abstract
Background: Nonfatal self-injury (NFSI) following a cancer diagnosis is a very serious mental health sequalae. Whether NFSI has an impact on patient outcomes is unknown. To help determine the impact and burden of NFSI in cancer care, this study examined the association between NFSI following a cancer diagnosis and subsequent overall survival (OS).
Methods: A retrospective population-based cohort study using linked administrative health care included patients with a new cancer diagnosis in 2007 through 2019. The exposure was NFSI (emergency department visit for self-injury of intentional or undetermined intent), treated as time-varying. The outcome was OS, as death from any cause measured from cancer diagnosis. Extended Cox multivariable models examined the association between NFSI and OS, adjusting for patient, cancer, and mental health history characteristics.
Results: Of 806,910 patients, 2,482 (0.31%) had NFSI at a median of 29 months (IQR, 11-57) from cancer diagnosis. Of those, 81 had >1 NFSI event. Patients with NFSI had inferior OS compared with those who had not yet experienced an NFSI (adjusted hazard ratio [HR], 1.73; 95% CI, 1.61-1.85). When treating NFSI as a count variable, there was an association between each additional NFSI and OS (adjusted HR, 1.17; 95% CI, 1.08-1.26).
Conclusions: NFSI following a cancer diagnosis was independently associated with inferior OS. This finding highlights NFSI as a crucial event for patients with cancer and supports the importance of identifying and providing treatment for patients with cancer with cancer-related distress, such as marked by higher risk of NFSI.
期刊介绍：
JNCCN—Journal of the National Comprehensive Cancer Network is a peer-reviewed medical journal read by over 25,000 oncologists and cancer care professionals nationwide. This indexed publication delivers the latest insights into best clinical practices, oncology health services research, and translational medicine. Notably, JNCCN provides updates on the NCCN Clinical Practice Guidelines in Oncology® (NCCN Guidelines®), review articles elaborating on guideline recommendations, health services research, and case reports that spotlight molecular insights in patient care.
Guided by its vision, JNCCN seeks to advance the mission of NCCN by serving as the primary resource for information on NCCN Guidelines®, innovation in translational medicine, and scientific studies related to oncology health services research. This encompasses quality care and value, bioethics, comparative and cost effectiveness, public policy, and interventional research on supportive care and survivorship.
JNCCN boasts indexing by prominent databases such as MEDLINE/PubMed, Chemical Abstracts, Embase, EmCare, and Scopus, reinforcing its standing as a reputable source for comprehensive information in the field of oncology.
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