[Functional state of the kidneys in patients with various types of cerebrovascular diseases].

Abstract

Objective: To study the functional state of the kidneys in men and women with various types of cerebrovascular diseases (CVD).

Material and methods: The study included 378 patients with CVD: transient ischemic attack (TIA), stroke (ischemic and hemorrhagic), and chronic brain ischemia. The average age of men and women was 61.4±13.0 and 63.8±11.8 years, respectively. The excretory function of the kidneys was assessed in all participants.

Results: TIA was recorded in 20.9% of men and 13.4% of women. Stroke was verified in 35.7% of patients (56.4% men and 34.3% women, p<0.05). Recurrent ischemic stroke was more common in men (12.9%) than in women (6.9%, p<0.05). The frequency of proteinuria was 34.1%, with nephrotic proteinuria and hematuria more often noted in men. The functional state of the kidneys (optimal, slightly reduced, moderately reduced, and significantly reduced excretory function) was identified in 37.8%, 34.1%, 17.7%, and 6.3% of patients, respectively. Severely reduced kidney function was recorded in 3.4% of patients. The glomerular filtration rate according to the CKD-EPI (67.9±24.1 ml/min), MDRD (62.9±22.8 ml/min), and Cockcroft-Gault (67.7±24.4 ml/min) formulas was lower in men compared to women (78.3±25.3 ml/min, 76.3±3.2 ml/min, 81.2±36.5 ml/min, p<0.05). In men and women, a correlation was established between pathomorphological changes on brain MRI and the level of red blood cells, glucose, total cholesterol and creatinine.

Conclusion: In patients with CVD, the frequency of proteinuria is 34.1%. Nephrotic proteinuria and hematuria are more common in men. Changes in the functional state of the kidneys are manifested as slight and moderate reductions in excretory function. In women, the excretory function of the kidneys and proteinuria are closely related to pathomorphological changes in the brain.