M. A. Agafonov, S. O. Kustov, M. G. Nikitina, I. V. Terekhova
{"title":"Hydrogels Based on Pluronic F127 As Nicotinic Acid and Nicotinamide Delivery Systems","authors":"M. A. Agafonov, S. O. Kustov, M. G. Nikitina, I. V. Terekhova","doi":"10.1134/S0036024424702753","DOIUrl":null,"url":null,"abstract":"<p>The structural and mechanical properties of hydrogels prepared from Pluronic F127 (20 wt %) are described and analyzed. The effects of nicotinic acid and nicotinamide (1 wt %) additions on the gelation process and the properties of Pluronic hydrogels are considered. The influence of the ionization state of nicotinic acid and nicotinamide molecules on interactions with the polymer matrix of the gel was studied by <sup>1</sup>H NMR spectroscopy. A kinetic study of the release and transmembrane transport of nicotinic acid and nicotinamide included in Pluronic hydrogels was performed. The influence of the acidity of the medium on the rate of release of drug compounds from hydrogels and on the transmembrane transfer was analyzed.</p>","PeriodicalId":767,"journal":{"name":"Russian Journal of Physical Chemistry A","volume":"98 14","pages":"3250 - 3256"},"PeriodicalIF":0.7000,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Physical Chemistry A","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S0036024424702753","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The structural and mechanical properties of hydrogels prepared from Pluronic F127 (20 wt %) are described and analyzed. The effects of nicotinic acid and nicotinamide (1 wt %) additions on the gelation process and the properties of Pluronic hydrogels are considered. The influence of the ionization state of nicotinic acid and nicotinamide molecules on interactions with the polymer matrix of the gel was studied by 1H NMR spectroscopy. A kinetic study of the release and transmembrane transport of nicotinic acid and nicotinamide included in Pluronic hydrogels was performed. The influence of the acidity of the medium on the rate of release of drug compounds from hydrogels and on the transmembrane transfer was analyzed.
期刊介绍：
Russian Journal of Physical Chemistry A. Focus on Chemistry (Zhurnal Fizicheskoi Khimii), founded in 1930, offers a comprehensive review of theoretical and experimental research from the Russian Academy of Sciences, leading research and academic centers from Russia and from all over the world.
Articles are devoted to chemical thermodynamics and thermochemistry, biophysical chemistry, photochemistry and magnetochemistry, materials structure, quantum chemistry, physical chemistry of nanomaterials and solutions, surface phenomena and adsorption, and methods and techniques of physicochemical studies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
