Imaging pharmacological and edible behavior of Sinomenii Caulis volatile organic compounds: chain model insight.

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of the Science of Food and Agriculture Pub Date : 2025-02-10 DOI:10.1002/jsfa.14169

Yecen Yao, Ming Guo, Yanan Wu, Mengdie Chen, Kaijie Ni, Mba Mikue María De Los Angeles Mibuy

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引用次数: 0

Abstract

Background: As a traditional Chinese medicine, Sinomenii Caulis (SC) has not only attracted much attention for its medicinal value, but also its volatile organic compounds have shown potential application in the agriculture and food fields. This study combined chain modeling (fingerprinting, machine learning, network pharmacology, metabolic analysis, spectroscopic experiments, and physical simulations) with the aim of interdisciplinarity exploring the potential applications of SC, at the interface of agriculture and food, especially in the area of food additives and active ingredient pharmacology.

Results: Palmitic acid (PA), linoleic acid (LA), and isomenthone (IM), which are closely related to depression, were shown to have good biocompatibility and stability, allowing them to cross the blood-brain barrier and exert their therapeutic effects on depression. Through metabolic analysis, these ingredients can be effectively metabolized in the human body, thus ensuring their safety in food. Through spectral analysis and physical simulation, it was verified that PA/LA/IM can interact with transporter proteins for in vivo transport.

Conclusion: The volatile organic compounds of SC can be used for the treatment of depression and as food additives, which can be fully transported in vivo to perform their roles, which is beneficial for the development of medicines and flavored foods. This study provides a feasible guide for the development of food products with pharmacological activities. © 2025 Society of Chemical Industry.

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.