Synthesis of the polymethoxyflavones nobiletin, tangeretin, isosinensetin, and gardenin A-D.

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-02-10 DOI:10.1039/d5ob00097a

Cheng-Hang Liu, Mengyang Xu, Jianke Du, Yang Ni, Qiyun Luo, Ziyan Wang, Wenyue Tan, Yunfang He, Linrun Zhang, Xiaodong Jia, Xingzeng Zhao

引用次数: 0

Abstract

We present a practical synthesis of 2'-hydroxy-3',4',5',6'-tetramethoxyacetophenone, a multi-substituted benzene derivative, via CuCl-catalyzed Ullmann-type coupling reaction with MeONa. 2'-Hydroxy-3',4',5',6'-tetramethoxyacetophenone is the key intermediate for the total synthesis of various polymethoxyflavones. Subsequently, nobiletin, tangeretin, and gardenin A-D, are synthesized from this intermediate.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.