A Novel “Three-in-One” Copper-Based Metal-Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy (Adv. Sci. 6/2025)

Abstract

“Three-in-One” Nanozyme for Tumor Therapy

This cover illustration depicts three angels supporting a net that captures tumor cells. In article number 2413422 by Lei Chen, Shuohui Dong, and co-workers, a “Three-in-One” Cu-based metalorganic framework nanozyme is developed, aiming to eradicate colorectal cancer and overcome chemoresistance through apoptosis, cuproptosis, and facilitating the degradation of hypoxia-inducible factor-1a.