Tannic acid-copper (II) complex-loaded nanoemulsion as a potential treatment for neuropsychiatric disorders

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-02-06 DOI:10.1016/j.matlet.2025.138189

Rafael Lima Saraiva , Matheus da Silva Campelo , Thaís Araújo Gomes Ferreira , Antônio Wlisses da Silva , Nágila Maria Pontes Silva Ricardo , Jane Eire Silva Alencar , Solange de Oliveira Pinheiro , Maria Elenir Nobre Pinho Ribeiro

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Abstract

The present study aimed to prepare nanoemulsions loaded with tannic acid-copper (II) complex (TA-Cu), as well as evaluate their potential for the treatment of neuropsychiatric diseases. The nanoemulsions were stabilized by proteoglycans from Agaricus blazei Murill mushroom (PAbM) and their physicochemical characterization showed droplet sizes lower than 250 nm, low polydispersity, ζ-potential greater than the modulus of 20 mV and spherical morphology. Assessment of acute toxicity and anxiolytic potential in adult zebrafish indicated the safety of the nanoformulations at the doses tested (LD₅₀ > 40 mg/kg), as well as their ability to reduce anxious-like behavior (4–40 mg/kg), whose activity is involved in the modulation of the GABAergic system. The results obtained for this new nanoformulation are promising to guide future clinical trials.

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive