Comparative elemental analysis of collagen vascular-associated lung diseases by in-air micro- PIXE, a pilot study

IF 1.4 3区物理与天体物理 Q3 INSTRUMENTS & INSTRUMENTATION

Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms Pub Date : 2025-02-11 DOI:10.1016/j.nimb.2025.165634

Yasuhiko Koga , Takahiro Satoh , Ryohei Yamagata , Yasuyuki Ishii , Wataru Kada , Takeshi Hisada , Kunio Dobashi

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引用次数: 0

Abstract

Background

Collagen vascular disease (CVD) is a systemic disease in which connective tissue abnormalities of systemic organs such as the skin, kidneys, lungs, and lymph nodes are caused by abnormal functions of the immune system. The cause of CVD has not been clarified yet, but it has been suggested that exposure to heavy metals and silica may be the cause of vasculitis and systemic sclerosis.

Purpose

In this study, we focused on the elemental analysis of lung tissues complicated with collagen vascular disease-associated interstitial lung disease (CVD-ILD) and investigated the relationship between inhaled elements and CVD-ILD.

Methods

We examined the inhaled elements in the lungs using in-air micro-particle-induced X-ray emission analysis (in-air micro-PIXE). Elemental analysis of lung tissue specimens was performed by using 5 cases of systemic sclerosis and 3 cases of aminoacyl-tRNA synthetase (ARS) antibody-positive dermatomyositis surgically resected by thoracoscopic lung biopsy. Control lung samples were obtained from early-stage lung cancer patients. The relative amounts of each elements divided with sulfur in the lung was statistically analyzed.

Results

There was a significant difference between CVD-ILD and the control lung in terms of inhaled silica/silicates. Furthermore, relative silica deposition was higher in scleroderma lungs compared to control lungs, but not in lungs from ARS-positive cases.

Conclusion

These results indicated that silica deposition in lung tissue may be involved in the pathogenesis of CVD-ILD, especially systemic sclerosis.

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来源期刊

Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms 物理-核科学技术

CiteScore

2.80

自引率

7.70%

发文量

231

审稿时长

1.9 months

期刊介绍： Section B of Nuclear Instruments and Methods in Physics Research covers all aspects of the interaction of energetic beams with atoms, molecules and aggregate forms of matter. This includes ion beam analysis and ion beam modification of materials as well as basic data of importance for these studies. Topics of general interest include: atomic collisions in solids, particle channelling, all aspects of collision cascades, the modification of materials by energetic beams, ion implantation, irradiation - induced changes in materials, the physics and chemistry of beam interactions and the analysis of materials by all forms of energetic radiation. Modification by ion, laser and electron beams for the study of electronic materials, metals, ceramics, insulators, polymers and other important and new materials systems are included. Related studies, such as the application of ion beam analysis to biological, archaeological and geological samples as well as applications to solve problems in planetary science are also welcome. Energetic beams of interest include atomic and molecular ions, neutrons, positrons and muons, plasmas directed at surfaces, electron and photon beams, including laser treated surfaces and studies of solids by photon radiation from rotating anodes, synchrotrons, etc. In addition, the interaction between various forms of radiation and radiation-induced deposition processes are relevant.