Ultra-widefield indocyanine green angiographic changes after photodynamic therapy in central serous chorioretinopathy. CERTAIN study report 3.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-02-04 DOI:10.1097/IAE.0000000000004414

Laurenz J B Pauleikhoff, Jennifer M Chang-Wolf, Roselie M H Diederen, Annette C Moll, Reinier O Schlingemann, Elon H C van Dijk, Camiel J F Boon

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引用次数: 0

Abstract

Purpose: Venous overload choroidopathy (VOC), showing pachyvessels, choroidal intervortex venous anastomoses (CVA), asymmetric venous drainage (AVD), choroidal vascular hyperpermeability (CVH) and increased choroidal thickness (CT), is observed in the vast majority of central serous chorioretinopathy (CSC) patients based on ultra-widefield indocyanine green angiography (UWF ICGA). This report investigates how photodynamic therapy (PDT) alters signs of VOC.

Methods: The CERTAIN study is a monocentric, retrospective study on consecutive CSC patients who underwent UWF ICGA. For this report, patients who underwent UWF ICGA twice were included. Two independent graders assessed changes in pachyvessels, CVA, AVD, CT and CVH when comparing pre- and post-PDT images of treated and untreated eyes.

Results: In total, 38 eyes (19 patients) were included. Of those, 19 eyes had undergone PDT and 19 had not. PDT had no significant effect on pachyvessels, CVA, and AVD (all p > 0.05). Only CT (-51 ± 48 µm vs. 1 ± 43 µm, p = 0.006) and CVH within the PDT treatment area (79% vs. 0% reduced CVH, p < 0.0001) were significantly decreased in treated vs. untreated eyes.

Conclusion: PDT reduced CT and CVH within the treatment area while not significantly altering the overall choroidal vascular architecture associated with VOC.

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.