Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan.

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Chien-An Tu, Chien-Feng Kuo, Chun-Ming Lee, Chang-Pan Liu, Hsiang-Kuang Tseng, Tseng-Yu Huang, Chih-Chen Lin, Hsun Chang, Winter Yu-Ning Lee, Fang-Ju Sun, Zu-Yi Sun, Pei-Ching Lian, Ming-Wei Cheng, Alice Ying-Jung Wu
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Abstract

HIV acquisition has been found to be associated with increased risk of cardiometabolic syndrome in the past. In this study, we attempt to delineate the associated factors of metabolic syndrome among persons living with HIV in a single medical center in Taiwan using mostly integrase inhibitors-based regimen as HAART. A cross-sectional study involving all people living with HIV (PLWH) aged ≥ 18 years who visited MacKay Memorial Hospital, Taipei, Taiwan between September 7, 2022 to January 31, 2023 was performed. A modified National Cholesterol Education Program ATP III definition of metabolic syndrome was used to define metabolic syndrome and body mass index was used as surrogate for waist circumference. 809 PLWH participated in the study, in which 81.3% of patients were on integrase inhibitor-based HAART regimen. The prevalence of metabolic syndrome was 10.0%, which is markedly lower than those reported in the literature. Age was a significant risk factor for metabolic syndrome. HIV-related factors (CD4, viral load, HAART regimen) did not affect the presence of metabolic syndrome. Prevalence rate of metabolic syndrome appeared to have declined among PLWH compared to previous reports, possibly secondary to widespread use of integrase inhibitors. Age remains a strong risk factor for the development of metabolic syndrome among PLWH.

Abstract Image

台湾北部某医疗中心HIV感染者代谢综合征患病率及相关因素分析
过去已经发现艾滋病毒感染与心脏代谢综合征的风险增加有关。在本研究中,我们尝试在台湾单一医疗中心,以整合酶抑制剂为主的方案作为HAART,来描述HIV感染者代谢综合征的相关因素。横断面研究纳入2022年9月7日至2023年1月31日在台湾台北麦凯纪念医院就诊的所有年龄≥18岁的HIV感染者(PLWH)。采用修改后的国家胆固醇教育计划ATP III对代谢综合征的定义来定义代谢综合征,体重指数作为腰围的替代指标。809名PLWH参与了这项研究,其中81.3%的患者采用了基于整合酶抑制剂的HAART方案。代谢综合征患病率为10.0%,明显低于文献报道。年龄是代谢综合征的重要危险因素。hiv相关因素(CD4、病毒载量、HAART方案)不影响代谢综合征的存在。与之前的报道相比,PLWH患者的代谢综合征患病率似乎有所下降,这可能是由于整合酶抑制剂的广泛使用。年龄仍然是PLWH患者发生代谢综合征的重要危险因素。
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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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