Role of genomics in liver transplantation for cholangiocarcinoma.

IF 1.8 4区医学 Q3 TRANSPLANTATION

Current Opinion in Organ Transplantation Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI:10.1097/MOT.0000000000001209

Nadine Soliman, Anaum Maqsood, Ashton A Connor

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引用次数: 0

Abstract

Purpose of review: The purpose of this review is to summarize the current knowledge of cholangiocarcinoma molecular biology and to suggest a framework for implementation of next-generation sequencing in all stages of liver transplantation. This is timely as recent guidelines recommend increased use of these technologies with promising results.

Recent findings: The main themes covered here address germline and somatic genetic alterations recently discovered in cholangiocarcinoma, particularly those associated with prognosis and treatment responses, and nascent efforts to translate these into contemporary practice in the peri-liver transplantation period.

Summary: Early efforts to translate molecular profiling to cholangiocarcinoma care demonstrate a growing number of potentially actionable alterations. Still lacking is a consensus on what biomarkers and technologies to adopt, at what scale and cost, and how to integrate them most effectively into care with the ambition of increasing the number of patients eligible for liver transplantation and improving their long-term outcomes.

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基因组学在胆管癌肝移植中的作用。

综述目的：本综述的目的是总结当前胆管癌分子生物学的知识，并建议在肝移植的各个阶段实施下一代测序的框架。这是及时的，因为最近的指南建议增加使用这些技术，并取得了有希望的结果。最近的发现：本文的主要主题是最近在胆管癌中发现的生殖系和体细胞遗传改变，特别是那些与预后和治疗反应相关的遗传改变，以及将这些改变转化为肝周围移植期当代实践的初步努力。摘要：早期将分子分析转化为胆管癌治疗的努力表明，越来越多的潜在可行的改变。对于采用何种生物标志物和技术，以何种规模和成本，以及如何最有效地将它们整合到护理中，以增加有资格接受肝移植的患者数量并改善其长期预后，目前仍缺乏共识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Organ Transplantation 医学-移植

CiteScore

4.10

自引率

4.50%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.