Effect of d-β-hydroxybutyrate on sleep quality in healthy participants: a randomized, double-blind, placebo-controlled study.

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-22 DOI:10.1093/bbb/zbaf017

Shohei Katsuya, Yoshikazu Kawata, Yosuke Kawamura, Jun Kawamura, Jun Tsubota

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Abstract

We investigated the effects of d-β-hydroxybutyric acid (D-BHB) on sleep quality in healthy Japanese adults. In this randomized, placebo-controlled, double-blind, parallel-group study, each group comprised 30 healthy Japanese adults. Participants received 1.5 g of D-BHB (low D-BHB group), 2.9 g of D-BHB (high D-BHB group), or a placebo beverage (placebo group) for 14 days. Before and after the intervention, the Oguri-Shirakawa-Azumi sleep inventory, middle-aged and aged version (OSA-MA), and sleep state test were conducted. After 14 days, compared to the placebo group, the OSA-MA scores for "Sleepiness on rising" and "Frequent dreaming" were significantly higher in both the low and high D-BHB groups. Additionally, the score for "Initiation and maintenance of sleep" was significantly higher in the low D-BHB group, and the score for "Refreshing on rising" was significantly higher in the high D-BHB group. We found that D-BHB can improve sleep quality in healthy Japanese adults.

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D-β-羟基丁酸酯对健康受试者睡眠质量的影响：一项随机、双盲、安慰剂对照研究

我们研究了D-β-羟基丁酸对健康日本成年人睡眠质量的影响。在这项随机、安慰剂对照、双盲、平行分组的研究中，每组由30名健康的日本成年人组成。他们分别服用1.5 g D-β-羟基丁酸（低D- bhb组）、2.9 g D-β-羟基丁酸（高D- bhb组）或安慰剂饮料（安慰剂组），持续14天。干预前后分别进行Oguri-Shirakawa-Azumi睡眠量表、中老年版（OSA-MA）和睡眠状态测试。14天后，与安慰剂组相比，低D-BHB组和高D-BHB组的OSA-MA“睡意上升”和“频繁做梦”得分明显更高。此外，低D-BHB组的“开始和维持睡眠”得分明显更高，高D-BHB组的“起床后提神”得分明显更高。我们发现D-β-羟基丁酸可以改善健康日本成年人的睡眠质量。

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).