{"title":"Toxicity of Ricin in Humans Following Oral Administration","authors":"G. T. Frumin","doi":"10.1134/S1070363224130073","DOIUrl":null,"url":null,"abstract":"<p>The relevance of this study stems from the need to quantify the toxicity of ricin when ingested orally. The aim of the research was to estimate the average lethal doses of ricin for humans via oral administration, using rats as a model organism for the prediction. Formulas for predicting the average lethal doses of ricin in humans are presented. The following methods were employed for this prediction: Yu.R. Rybolovlev and R.S. Rybolovlev’s methods, the American Environmental Protection Agency’s approach, the methods of D.B. Laurence and A.L. Bacharach, and the method developed by the author of this study. The predicted values for the average lethal doses of ricin in humans, along with their average value and confidence interval, are provided.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 13","pages":"3496 - 3499"},"PeriodicalIF":0.9000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363224130073","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The relevance of this study stems from the need to quantify the toxicity of ricin when ingested orally. The aim of the research was to estimate the average lethal doses of ricin for humans via oral administration, using rats as a model organism for the prediction. Formulas for predicting the average lethal doses of ricin in humans are presented. The following methods were employed for this prediction: Yu.R. Rybolovlev and R.S. Rybolovlev’s methods, the American Environmental Protection Agency’s approach, the methods of D.B. Laurence and A.L. Bacharach, and the method developed by the author of this study. The predicted values for the average lethal doses of ricin in humans, along with their average value and confidence interval, are provided.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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