New gentisyl alcohol derivatives from Aspergillus japonicas collected from the Arctic 6700-4 sea area

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-01-27 DOI:10.1016/j.tet.2025.134507

Man Zhang , Jia Rui , Chong Yu , Mengyang Sun , Dan Gou , Haifeng Wang , Guangyue Su

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Abstract

Six compounds were isolated from the ethyl acetate extract of the marine fungus Aspergillus japonicas, which was collected from surface seawater in the Arctic 6700-4 sea area, including two new gentisyl alcohol derivatives named dimeric terrestrol I (1) and dimeric terrestrol J (2), along with four known compounds, dimeric terrestrol E (3), 2-(hydroxymethyl) benzene-1,4-diol (4), methyl (2′,5′-dihydroxyphenyl) acetate (5), and toluhydroquinone (6). All compounds were characterized and established by spectral analysis of 1D NMR and reported data, confirmed using 2D NMR and HR-MS for new compounds. All the compounds were tested for in vitro activity. The results show that dimeric terrestrol J (2), alleviated lipopolysaccharide (LPS)-induced BV2 microglial cell death by reducing the generation of nitric oxide (NO), has strong anti-inflammatory activity and is even stronger than Dexamethasone (DEX). Furthermore, molecular docking was conducted to verify the affinity between the protein and ligand.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.