Different molecular weight fucogalactans from Macrocybe titans mushroom promote distinct effect on breast cancer cell death

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-01-25 DOI:10.1016/j.carbpol.2025.123318

Shayane da Silva Milhorini , Renata Rutckeviski , Ariana Centa , Fhernanda Ribeiro Smiderle , Matheus Zavadinack , Fábio Rogério Rosado , Marcello Iacomini

{"title":"Different molecular weight fucogalactans from Macrocybe titans mushroom promote distinct effect on breast cancer cell death","authors":"Shayane da Silva Milhorini , Renata Rutckeviski , Ariana Centa , Fhernanda Ribeiro Smiderle , Matheus Zavadinack , Fábio Rogério Rosado , Marcello Iacomini","doi":"10.1016/j.carbpol.2025.123318","DOIUrl":null,"url":null,"abstract":"<div><div>There is an incessant search for new therapies against cancer, able to unite effectiveness with specificity, leading to higher survival rates and lower deleterious effects. Herein, two fucogalactans (F-1 and F-2), isolated from <em>Macrocybe titans</em>, showed a (1 → 6)-linked α-D-Gal<em>p</em> main chain partially substituted at O-2 by non-reducing end units of α-L-Fuc<em>p</em>, with different M<sub><em>w</em></sub>, being F-2 > 20 times higher than F-1. Both fucogalactans induced cell cycle arrest of MDA-MB-231 cells in G1 phase after 120 h of treatment. However, only F2 resulted in increased apoptosis and necrosis. For the MCF-7 cell line, no changes in the cell cycle and cell death were observed at 120 h. The non-tumoral cell line (VERO) was not affected. The results confirmed that polysaccharides with different M<sub><em>w</em></sub> may have distinct effects and therefore this is an important feature to be considered on investigating anti-cancer treatments.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"354 ","pages":"Article 123318"},"PeriodicalIF":10.7000,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbohydrate Polymers","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0144861725000992","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

There is an incessant search for new therapies against cancer, able to unite effectiveness with specificity, leading to higher survival rates and lower deleterious effects. Herein, two fucogalactans (F-1 and F-2), isolated from Macrocybe titans, showed a (1 → 6)-linked α-D-Galp main chain partially substituted at O-2 by non-reducing end units of α-L-Fucp, with different M_w, being F-2 > 20 times higher than F-1. Both fucogalactans induced cell cycle arrest of MDA-MB-231 cells in G1 phase after 120 h of treatment. However, only F2 resulted in increased apoptosis and necrosis. For the MCF-7 cell line, no changes in the cell cycle and cell death were observed at 120 h. The non-tumoral cell line (VERO) was not affected. The results confirmed that polysaccharides with different M_w may have distinct effects and therefore this is an important feature to be considered on investigating anti-cancer treatments.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.