{"title":"Issue Information","authors":"","doi":"10.1002/msp2.56","DOIUrl":null,"url":null,"abstract":"<p><b>COVER</b>: He <i>et al</i>. found that hypoxia and radiotherapy can reverse the promoting effect of cancer-associated fibroblasts (CAFs) on the migration and invasion of head and neck squamous cell carcinoma (HNSCC), which may weaken the inhibitory effect of <i>ENDOU</i> expression in HNSCC by reducing the delivery of miR-23b-5p via CAF-derived extracellular vesicles. This discovery provides new insights into the role of stromal components in tumor regulation and suggests that <i>ENDOU</i> could serve as a biomarker for HNSCC. See pages 275–289 by for details.</p>","PeriodicalId":100882,"journal":{"name":"Malignancy Spectrum","volume":"1 4","pages":"i-vi"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/msp2.56","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Malignancy Spectrum","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/msp2.56","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
COVER: He et al. found that hypoxia and radiotherapy can reverse the promoting effect of cancer-associated fibroblasts (CAFs) on the migration and invasion of head and neck squamous cell carcinoma (HNSCC), which may weaken the inhibitory effect of ENDOU expression in HNSCC by reducing the delivery of miR-23b-5p via CAF-derived extracellular vesicles. This discovery provides new insights into the role of stromal components in tumor regulation and suggests that ENDOU could serve as a biomarker for HNSCC. See pages 275–289 by for details.
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