Effect of Precise Pulmonary Rehabilitation Nursing Intervention Combined With Simultaneous Inhalation Therapy and Noninvasive Ventilation for Chronic Obstructive Pulmonary Disease Patients With Chronic Hypercapnic Respiratory Failure

IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM
Jian Xiao, Yan Wu, Limei Wang, Hong Zhou
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Abstract

Background

Chronic obstructive pulmonary disease (COPD) is a progressive heterogeneous pulmonary disorder with an increasing high prevalence, particularly in the older. The objective of this study is to assess the effect of noninvasive ventilation combined with simultaneous nebulization during precise pulmonary rehabilitation nursing intervention in COPD patients with chronic hypercapnic respiratory failure, compared to pulmonary rehabilitation nursing alone.

Methods

In total, 240 elderly COPD patients with chronic hypercapnic respiratory failure were randomized controlled into either a precise pulmonary rehabilitation nursing model group (control group) or noninvasive ventilation coupled with simultaneous nebulization during pulmonary rehabilitation nursing (intervention group). For our evaluation, we considered general information, pulmonary function, exercise endurance, mental health, blood gas, inflammation, COPD severity, life quality, and overall efficacy of subjects before and on the 5-, 30-, 90-day intervention.

Results

The total effective rates were 95% and 77.5% in the intervention and control group, respectively. In detail, the intervention group showed statistically significant improvements in lung function, exercise endurance, psychological health, blood gas inflammation, overall severity, and quality of life outcomes, especially on the 90-day intervention (p < 0.001).

Conclusions

The complex COPD patients with chronic hypercapnic respiratory failure may confer more gains from precise pulmonary rehabilitation nursing intervention combined with simultaneous inhalation therapy and noninvasive ventilation.

精准肺康复护理干预联合同步吸入治疗及无创通气治疗慢性阻塞性肺疾病合并慢性高碳酸血症性呼吸衰竭的效果
慢性阻塞性肺疾病(COPD)是一种进行性异质性肺疾病,发病率越来越高,尤其是在老年人中。本研究的目的是评估无创通气联合同步雾化在COPD合并慢性高碳酸血症性呼吸衰竭患者精准肺康复护理干预中的效果,并与单纯肺康复护理进行比较。方法将240例老年COPD合并慢性高碳酸血症性呼吸衰竭患者随机分为精准肺康复护理模型组(对照组)和无创通气同时雾化肺康复护理组(干预组)。在我们的评估中,我们考虑了受试者在5天、30天、90天干预前后的一般信息、肺功能、运动耐力、心理健康、血气、炎症、COPD严重程度、生活质量和总体疗效。结果干预组总有效率为95%,对照组总有效率为77.5%。具体而言,干预组在肺功能、运动耐力、心理健康、血气炎症、总体严重程度和生活质量结局方面均有统计学意义上的改善,特别是在90天的干预中(p <;0.001)。结论对合并慢性高碳酸血症性呼吸衰竭的复杂慢性阻塞性肺疾病患者,实施精准的肺康复护理干预,结合同步吸入治疗和无创通气,可获得更大的疗效。
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来源期刊
Clinical Respiratory Journal
Clinical Respiratory Journal 医学-呼吸系统
CiteScore
3.70
自引率
0.00%
发文量
104
审稿时长
>12 weeks
期刊介绍: Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)
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