Cytoplasmic SALL4-A isoform expression as a diagnostic marker of less aggressive tumor behavior in gastric cancer.

IF 2.5 3区医学 Q3 ONCOLOGY

World Journal of Surgical Oncology Pub Date : 2025-02-04 DOI:10.1186/s12957-025-03681-w

Saeed Rahmani, Amirhesam Babajani, Maryam Abolhasani, Roya Ghods, Elham Kalantari, Zahra Madjd

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引用次数: 0

Abstract

Background: Gastric cancer (GC) poses significant challenges globally, ranking fifth in incidence and fourth in cancer-related mortality. SALL4, a stem cell transcription factor with multiple isoforms, includes SALL4-A as its full-length form. This study aims to evaluate the diagnostic potential of SALL4-A isoform expression in GC and its clinical significance.

Method: Immunohistochemical (IHC) analysis was conducted on Tissue Micro Array (TMA) slides from 167 GC patients. Clinicopathological parameters were correlated with SALL4-A expression, and survival analysis was performed. Diagnostic performance was assessed using metrics such as sensitivity, specificity, and area under the curve (AUC).

Results: SALL4-A exhibited distinct cytoplasmic expression in GC, correlating with lower histological grade (p = 0.003) and TNM stage (p = 0.003), particularly in the intestinal subtype. Diagnostic evaluation showed an AUC of 0.803 for cytoplasmic expression, demonstrating high diagnostic potential. However, SALL4-A expression did not show significant prognostic value.

Conclusion: Cytoplasmic SALL4-A expression in GC is associated with less aggressive tumor phenotypes and shows promise as a diagnostic marker. Further research is warranted to elucidate its mechanistic role and potential integration into clinical practice.

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背景：胃癌（GC）是全球面临的重大挑战，其发病率居全球第五位，死亡率居全球第四位。SALL4是一种具有多种异构体的干细胞转录因子，其中SALL4-A是其全长形式。本研究旨在评估 SALL4-A 同工型表达在 GC 中的诊断潜力及其临床意义：方法：对 167 例 GC 患者的组织微阵列（TMA）切片进行免疫组化（IHC）分析。临床病理参数与 SALL4-A 表达相关，并进行了生存分析。使用灵敏度、特异性和曲线下面积（AUC）等指标评估诊断效果：结果：SALL4-A在GC中表现出明显的细胞质表达，与较低的组织学分级（p = 0.003）和TNM分期（p = 0.003）相关，尤其是在肠道亚型中。诊断评估显示，细胞质表达的 AUC 为 0.803，显示出很高的诊断潜力。然而，SALL4-A的表达并没有显示出显著的预后价值：结论：SALL4-A在GC中的细胞质表达与侵袭性较低的肿瘤表型相关，有望成为一种诊断标志物。需要进一步研究以阐明其机理作用以及与临床实践结合的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Surgical Oncology ONCOLOGY-SURGERY

CiteScore

4.70

自引率

15.60%

发文量

362

审稿时长

3 months

期刊介绍： World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics. Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.