Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in China.

IF 4.6 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2025-01-21 eCollection Date: 2024-01-01 DOI:10.3389/fcimb.2024.1497082

Jiejun Shi, Jianhua Chen, Qianjiang Ding, Guoqing Qian, Zeqin Zhang, Qifa Song

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引用次数: 0

Abstract

Background: Lateral flow assay (LFA) has demonstrated high sensitivity and specificity for diagnosing cryptococcosis. However, its role in predicting therapeutic efficacy for pulmonary cryptococcosis (PC) remains underexplored.

Methods: We conducted a retrospective analysis of HIV-negative patients with PC to describe the clinical profile and identify potential predictors of radiological prognosis.

Results: All the 168 participants received antifungal therapy with a triazole agent. Of these, 84.5% experienced partial or complete absorption of pulmonary lesions. The results of the gamma test, chi-square trend test, and ordinal logistic regression all indicated that both baseline LFA and changes in LFA after treatment were significant predictors of imaging prognosis. The degree of radiological improvement was inversely associated with the baseline LFA positive grade(P for linear-by-linear association: 0.011, Spearman correlation coefficient = -0.17; γ= -0.368, P = 0.045). Patients with a decrease in LFA after therapy had significantly better radiological outcomes compared to those with equal or increased LFA(linear-by-linear association, P = 0.014, Spearman correlation coefficient = 0.188; γ = 0.371, P = 0.012). Additionally, favorable outcomes were more likely in patients with lesions confined to the right lung.

Conclusions: LFA shows potential of monitoring radiological outcomes in pulmonary cryptococcosis.

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背景：侧流检测法（LFA）在诊断隐球菌病方面具有很高的灵敏度和特异性。然而，它在预测肺隐球菌病（PC）疗效方面的作用仍未得到充分探索：我们对 HIV 阴性的 PC 患者进行了回顾性分析，以描述其临床特征并确定放射学预后的潜在预测因素：所有168名参与者均接受了三唑类药物的抗真菌治疗。其中，84.5%的患者肺部病变部分或完全吸收。伽马检验、卡方趋势检验和序数逻辑回归的结果均表明，基线LFA和治疗后LFA的变化均可显著预测影像学预后。放射学改善程度与基线 LFA 阳性等级成反比（线性相关 P：0.011，线性相关 P：0.011，线性相关 P：0.011，线性相关 P：0.011）：0.011，斯皮尔曼相关系数=-0.17；γ=-0.368，P=0.045）。与 LFA 相同或增加的患者相比，治疗后 LFA 减少的患者的放射学结果明显更好（线性相关，P = 0.014，Spearman 相关系数 = 0.188；γ = 0.371，P = 0.012）。此外，病变局限于右肺的患者更有可能获得良好的预后：LFA显示了监测肺隐球菌病放射学结果的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.