Establishment of purification techniques for alpha-lipoic acid derivative, sodium zinc histidine dithiooctanamide using ethanol-based crystallization and suspension methods

IF 2.2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Iranian Chemical Society Pub Date : 2024-12-20 DOI:10.1007/s13738-024-03151-2

Naoya Ohmori, Takamitsu Miyagi, Toshiaki Nakano, Simon Peter Bahau, Yohei Kono, Toshikazu Adachi, Satoshi Hiratsuka, Shigeru Goto, Masafumi Inomata, Takeshi Goto

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引用次数: 0

Abstract

Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well defined as a therapy for preventing diabetic polyneuropathies, scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.

Sodium zinc histidine dithiooctanamide (DHL-HisZn_Na) is a water-soluble substance, with strong antioxidant and anti-inflammatory properties, similar to α-lipoic acid with histidine bound to α-lipoic acid and zinc chelated with sulfur atoms. DHL-HisZn_Na slowly loses its stability under dry conditions in the dark and under refrigeration. Purification is essential for use after long-term storage. In this study, ethanol crystallization and suspension methods were utilized in development for the first time as purification methods for DHL-HisZn_Na.

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来源期刊

Journal of the Iranian Chemical Society 化学-化学综合

CiteScore

4.40

自引率

8.30%

发文量

230

审稿时长

5.6 months

期刊介绍： JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.