An efficient method for thioesterification of carboxylic acid with sulfenylchloride

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-02-01 DOI:10.1016/j.tet.2024.134422

Jiahong Chen, Mengke Wang, Weichun Huang, You Zi

引用次数: 0

Abstract

A mild and convenient method for synthesizing thioesters has been developed, from sulfenylchlorides and carboxylic acids via a phosphine mediated umpolung process. This approach efficiently produces a broad spectrum of thioesters from readily available carboxylic acids, including primary, secondary, and tertiary types, as well as bioactive molecules. The successful gram-scale reactions also validate its scalability and practical application.

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以亚磺酰氯和羧酸为原料，通过膦介导的umpolung 工艺，开发出了一种温和、便捷的硫代酯类合成方法。这种方法能从现成的羧酸（包括伯、仲和叔羧酸）以及生物活性分子中有效地生成多种硫代酯。克级反应的成功也验证了该方法的可扩展性和实际应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.