Cp∗Co(III)-catalyzed C–H amidation of 2-arylimidazo[1,2-α]pyridines with dioxazolones

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-02-01 DOI:10.1016/j.tet.2024.134420

Yongqi Yu , Jinjin Bai , Mengdan You , Jiajia Yu , Wenguang Li , Yuanjiu Xiao , Shiyu Zhang , Zhenhua Xiong , Ze Tan

引用次数: 0

Abstract

A highly simple and practical Cp∗Co(III)-catalyzed C–H amidation of 2-arylimidazo[1,2-α]pyridines was developed, during which dioxazolones were used as the amidating reagents. This method features excellent regioselectivity, operational simplicity, and good substrate compatibility, and various amidated 2-arylimidazoheterocycles were efficiently synthesized in 34–81 % yields. Furthermore, mechanistic studies reveal that the C–H bond cleavage may be involved in the turnover-limiting stage.

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Cp∗Co(III)催化的 2-芳基咪唑并[1,2-α]吡啶与二恶唑酮的 C-H 氨化反应

开发了一种高度简单实用的 Cp∗Co(III)催化 2-芳基咪唑并[1,2-α]吡啶的 C-H 酰胺化反应，其间使用二恶唑酮类化合物作为酰胺化试剂。该方法具有极佳的区域选择性、操作简便性和良好的底物相容性，以 34%-81% 的产率高效合成了各种酰胺化 2-芳基咪唑杂环。此外，机理研究表明，C-H 键的裂解可能参与了周转限制阶段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.