Rapid food desensitization associated with omalizumab before oral immunotherapy

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal Pub Date : 2025-02-01 DOI:10.1016/j.waojou.2025.101032

Bruna Giavina-Bianchi MD, Pedro Giavina-Bianchi MD, PhD

引用次数: 0

Abstract

In this report, we propose an innovative approach to managing patients with food-induced anaphylaxis by performing rapid food desensitization alongside the use of omalizumab as an introductory step to oral immunotherapy. This combined strategy aims to enhance both the safety and effectiveness of the process, which seeks to induce immunological tolerance to food allergens, while reducing the risk of severe allergic reactions during treatment. The use of omalizumab helps prevent anaphylaxis and improves the patient's ability to tolerate the allergen. Rapid desensitization offers significant time and cost savings. As more scientific evidence supports rapid food desensitization, it could become a valuable tool for clinicians managing food-induced anaphylaxis, offering a promising avenue for the treatment of food allergies, especially in complex cases.

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口服免疫治疗前与omalizumab相关的快速食物脱敏

在本报告中，我们提出了一种创新的方法，通过实施快速食物脱敏，同时使用omalizumab作为口服免疫治疗的入门步骤，来管理食物性过敏反应患者。这一综合策略旨在提高该过程的安全性和有效性，该过程旨在诱导对食物过敏原的免疫耐受，同时降低治疗期间严重过敏反应的风险。使用omalizumab有助于预防过敏反应，提高患者对过敏原的耐受能力。快速脱敏可显著节省时间和成本。随着越来越多的科学证据支持快速食物脱敏，它可能成为临床医生管理食物引起的过敏反应的有价值的工具，为治疗食物过敏提供了一条有希望的途径，特别是在复杂的病例中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Allergy Organization Journal Immunology and Microbiology-Immunology

CiteScore

9.10

自引率

5.90%

发文量

审稿时长

9 weeks

期刊介绍： The official pubication of the World Allergy Organization, the World Allergy Organization Journal (WAOjournal) publishes original mechanistic, translational, and clinical research on the topics of allergy, asthma, anaphylaxis, and clincial immunology, as well as reviews, guidelines, and position papers that contribute to the improvement of patient care. WAOjournal publishes research on the growth of allergy prevalence within the scope of single countries, country comparisons, and practical global issues and regulations, or threats to the allergy specialty. The Journal invites the submissions of all authors interested in publishing on current global problems in allergy, asthma, anaphylaxis, and immunology. Of particular interest are the immunological consequences of climate change and the subsequent systematic transformations in food habits and their consequences for the allergy/immunology discipline.