Synthesis of a new CTX derivative with naphthalene units

Abstract

CTX[P(O)Ph], previously reported by our group, acts as a crystallization chaperone to determine the structures of oily molecules at room temperature. However, its small cavity limits access to guest molecules, emphasizing the need for new analogues with larger cavities. In this study, we report a new analogue of CTX[P(O)Ph], termed (CTH-2-[P(O)Ph]), which has a bigger size of bowl-shaped structure with naphthalene units characterized by its rigidity and completely locked conformation. Crystal of CTH-2-[P(O)Ph] is successfully obtained from a saturated acetonitrile solution. Additionally, we investigated the host–guest behavior of CTH-2-[P(O)Ph] with 1-ethylpyridinium chloride (EPyCl) in acetonitrile.