Asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes using a thiourea organocatalyst

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-01-30 DOI:10.1016/j.tetlet.2024.155392

Taro Koda , Hiroshi Akutsu , Mitsuaki Suzuki , Kosuke Nakashima , Shin-ichi Hirashima , Akihiro Yoshida , Tsuyoshi Miura , Takashi Yamanoi

引用次数: 0

Abstract

The asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes using a pyrrolidine–thiourea organocatalyst yielded ε-regioselective addition products in high yields with high enantioselectivities. This work represents the first example of asymmetric ε-regioselective conjugate addition of 2-furfuryl ketones to nitroalkenes.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.