{"title":"Ambient temperature activation of diaryliodonium salts: Atom-economic route towards the ex-situ metal-free synthesis of N-methyldiarylamine","authors":"Dhanashri A. Sable, Anant R. Kapdi","doi":"10.1016/j.tetlet.2024.155436","DOIUrl":null,"url":null,"abstract":"<div><div>An atom economic route for the synthesis of <em>N</em>-methylarylamines via the ambient temperature activation of diaryliodonium salts using an ex-situ generated HNMe<sub>2</sub> has been disclosed and a scale-up reaction was also performed to demonstrate the scalability of the developed protocol.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"155 ","pages":"Article 155436"},"PeriodicalIF":1.5000,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924005318","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
An atom economic route for the synthesis of N-methylarylamines via the ambient temperature activation of diaryliodonium salts using an ex-situ generated HNMe2 has been disclosed and a scale-up reaction was also performed to demonstrate the scalability of the developed protocol.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.