Tuberculosis and drug resistance in a region of Southern Italy among native and foreign-born populations: A twelve-year province-based study

IF 2 Q3 INFECTIOUS DISEASES

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Pub Date : 2025-02-01 DOI:10.1016/j.jctube.2025.100512

Salvatore Rotundo , Salvatore Nisticò , Helen Linda Morrone , Luigia Gallo , Saveria Dodaro , Carmelo Papola , Pasquale Minchella , Giovanni Matera , Francesca Greco , Luigi Principe , Lorenzo Antonio Surace , Francesco Lucia , Francesca Serapide , Alessandro Russo , Carlo Torti , Enrico Maria Trecarichi , the Calabria TB group

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引用次数: 0

Abstract

Tuberculosis (TB) remains a significant global health challenge, with the World Health Organization (WHO) aiming for a 95% reduction in TB deaths by 2030. Disparities in TB detection persist, particularly regarding gender, immigration status, and resistance patterns. In Calabria, Italy—a key entry point for migrants from high-TB-incidence regions—TB poses a notable public health risk. This multicenter, retrospective study examines newly diagnosed TB cases in Calabria from 2012 to 2023, focusing on rifampicin-resistant TB (RR-TB).

During this period, 800 TB cases were diagnosed, with 270 (33.7 %) in native-born Italians and 530 (66.2 %) in foreign-born individuals, showing significant differences in age (p < 0.001) and gender (p = 0.013). Among 685 patients of this cohort with available HIV status, 24 (3.5 %) were people living with HIV (PLWH), primarily from Africa, and diagnosed at higher rates of RR-TB (p < 0.001). TB cases varied by province, correlating with specific birthplaces. A total of 27 (3.4 %) RR-TB cases were identified, with heightened resistance to multiple drugs. Among these strains, 20 (74.1 %) were isoniazid-resistant (MDR-TB).

This study underscores the need for comprehensive TB control strategies, especially regarding co-infection with HIV and the emergence of drug-resistant strains, emphasizing the importance of early detection and tailored management in Southern Italy.

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意大利南部一个地区本地和外国出生人口中的结核病和耐药性：一项为期12年的省级研究

结核病仍然是一项重大的全球卫生挑战，世界卫生组织（世卫组织）的目标是到2030年将结核病死亡人数减少95%。结核病检测方面的差异仍然存在，特别是在性别、移民身份和耐药性模式方面。在意大利卡拉布里亚，结核病是结核病高发地区移民的关键入境点，结核病构成了显著的公共卫生风险。这项多中心回顾性研究调查了2012年至2023年卡拉布里亚新诊断的结核病病例，重点是利福平耐药结核病（RR-TB）。在此期间，诊断出800例结核病病例，其中270例（33.7%）为意大利本土出生的人，530例（66.2%）为外国出生的人，显示出年龄上的显着差异(p <；0.001)和性别（p = 0.013）。在该队列的685例可获得艾滋病毒感染的患者中，24例（3.5%）是艾滋病毒感染者（PLWH），主要来自非洲，诊断为RR-TB的比例较高(p <；0.001)。结核病病例因省而异，与具体的出生地有关。共发现27例（3.4%）耐药结核病例，对多种药物的耐药性增强。其中20株（74.1%）耐异烟肼（MDR-TB）。这项研究强调了制定综合结核病控制战略的必要性，特别是在艾滋病毒合并感染和耐药菌株出现方面，强调了在意大利南部早期发现和量身定制管理的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Medicine-Pulmonary and Respiratory Medicine

CiteScore

4.00

自引率

5.00%

发文量

审稿时长

30 weeks

期刊介绍： Journal of Clinical Tuberculosis and Mycobacterial Diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including (but not limited to) epidemiology, clinical investigation, transmission, diagnosis, treatment, drug-resistance and public policy, and encourages the submission of clinical studies, thematic reviews and case reports. Journal of Clinical Tuberculosis and Mycobacterial Diseases is an Open Access publication.