Genetic background of Diego blood group in Saudi Arabia

IF 3.7 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of King Saud University - Science Pub Date : 2024-12-01 DOI:10.1016/j.jksus.2024.103571

Amr J. Halawani , Saif Elden B. Abdalla , Abdullah Meshi , Ghalia Shamlan , Mahmoud M. Habibullah

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引用次数: 0

Abstract

Background

Multiply-transfused patients are prevalent in Jazan region, Saudi Arabia. Alloimmunization may occur in case of red cell incompatibility. Therefore, extensive serotyping for other blood groups is essential. Two alleles of the Diego (DI) blood group system, DI*A and DI*B encode the main DI antigens Di(a + b–) and Di(a–b+), respectively. Anti-Di^a and anti-Di^b can be involved in transfusion reactions and pregnancy issues. This study aimed to investigate the allele and genotype frequencies of the DI blood groups in Jazan Province of Saudi Arabia.

Methods

One-hundred-fifty samples were collected from Saudi blood donors in Jazan Province. DNA was extracted and sequence-specific primers were designed to amplify the SNV region (rs2285644), which distinguishes the DI*A allele from the DI*B allele. The resulting PCR amplicons were sequenced.

Results

The frequency of DI*B alleles was 100 %, while the DI*A allele was not observed. Therefore, the only detected genotype was DI*B/DI*B at 100 %.

Conclusions

This study reported the allele and genotype frequencies of the DI blood group system in Saudi Arabia. This study may help establish a national database for blood groups in Jazan region. Moreover, it may help to reduce the risk of alloimmunization by providing matching blood units.

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来源期刊

Journal of King Saud University - Science Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

2.60%

发文量

642

审稿时长

49 days

期刊介绍： Journal of King Saud University – Science is an official refereed publication of King Saud University and the publishing services is provided by Elsevier. It publishes peer-reviewed research articles in the fields of physics, astronomy, mathematics, statistics, chemistry, biochemistry, earth sciences, life and environmental sciences on the basis of scientific originality and interdisciplinary interest. It is devoted primarily to research papers but short communications, reviews and book reviews are also included. The editorial board and associated editors, composed of prominent scientists from around the world, are representative of the disciplines covered by the journal.