The Medication-Related Burden Quality of Life (MRB-QoL) tool: A confirmatory factor analysis of the Arabic version

IF 1.8 Q3 PHARMACOLOGY & PHARMACY

Exploratory research in clinical and social pharmacy Pub Date : 2025-01-15 DOI:10.1016/j.rcsop.2025.100568

Sundos Q. Al-Ebrahim , Khadija Hafidh , Mahir Jallo , Mais M. Mauwfak , Mohamed Nassef , Hamzah Alzubaidi , Jeff Harrison , Timothy F. Chen , Mohammed A. Mohammed

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Abstract

Background

The Medication-Related Burden Quality of Life (MRB-QoL) Arabic version is a 31-item valid and reliable measure of medication burden on functioning and well-being.

Objective

To examine the factor structure of the MRB-QoL Arabic in a sample of adults living with long-term conditions (LTC).

Methods

Three hundred forty-three patients (≥ 18 years old) living with at least one LTC were recruited from 4 tertiary hospitals in the United Arab Emirates. Confirmatory factor analysis (CFA) was performed using Maximum likelihood estimation with bootstrap. Two models (first order and second order) were examined. Model fit indices, composite reliability (CR), and average variance extracted (AVE) were used to assess the model's goodness of fit, reliability, and convergent/discriminant validity, respectively. The model's fit was evaluated using absolute fit, comparative fit, and parsimony-adjusted indices. The RMSEA and SRMR ≤0.08, χ²/df < 5, and CFI, IFI, and TLI ≥ 0.90 were considered indicators of good model fit. PNFI and PCFI >0.5 were also considered as indicators of good fit. CR ≥ 0.7, AVE ≥ 0.5, and AVE greater than squared factors correlation were considered as evidence indicating reliability, convergent validity, and discriminant validity, respectively.

Results

The first-order model showed an excellent fit (χ2/df = 3.262, RMSEA = 0.08, SRMR = 0.05, CFI = 0.913, TLI = 0.914, IFI = 0.914, PNFI = 0.810, PCFI = 0.841) as did the second-order model (χ2/df = 2.845, RMSEA = 0.073, SRMR = 0.072, CFI = 0.934, TLI = 0.923, IFI = 0.915, PNFI = 0.820, PCFI = 0.851). All domains of the MRB-QoL met the convergent/discriminant validity and reliability criteria.

Conclusions

The study supports the factor structure from previous research and confirms the MRB-QoL Arabic as a valid and reliable measure. This tool can be used to assess medicines burden from patient perspectives and facilitate person-centred care in medicines optimisation services across Arabic-speaking countries.

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药物相关负担生活质量（MRB-QoL）工具：阿拉伯版本的验证性因素分析

药物相关负担生活质量（MRB-QoL）阿拉伯语版本是一个31项有效和可靠的药物负担对功能和福祉的测量。目的探讨成人长期疾病（LTC）患者阿拉伯语生活质量量表（MRB-QoL）的因子结构。方法从阿拉伯联合酋长国的4家三级医院招募343名至少有一种LTC的患者（≥18岁）。验证性因子分析（CFA）采用最大似然估计与bootstrap。对两个模型（一阶和二阶）进行了检验。模型拟合指标、复合信度（CR）和平均方差提取（AVE）分别用于评估模型的拟合优度、信度和收敛/区分效度。使用绝对拟合、比较拟合和简约调整指数来评估模型的拟合。RMSEA和SRMR≤0.08,χ2/df <；5，认为CFI、IFI和TLI≥0.90为模型拟合良好的指标。PNFI和PCFI >；0.5也被认为是良好的拟合指标。CR≥0.7,AVE≥0.5，AVE大于平方因子相关，分别作为信度、收敛效度和区分效度的证据。结果一阶模型拟合良好（χ2/df = 3.262, RMSEA = 0.08, SRMR = 0.05, CFI = 0.913, TLI = 0.914, IFI = 0.914, PNFI = 0.810, PCFI = 0.841），二阶模型拟合良好（χ2/df = 2.845, RMSEA = 0.073, SRMR = 0.072, CFI = 0.934, TLI = 0.923, IFI = 0.915, PNFI = 0.820, PCFI = 0.851）。MRB-QoL的所有领域均满足收敛/判别效度和信度标准。结论本研究支持了前人研究的因子结构，证实了MRB-QoL阿拉伯语是一种有效可靠的测量方法。该工具可用于从患者角度评估药物负担，并促进阿拉伯语国家在药物优化服务中以人为本的护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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