Mapping transcriptomic profiles of seminal vesiculitis and experimental verification

IF 2.4 3区医学 Q2 UROLOGY & NEPHROLOGY

Asian Journal of Urology Pub Date : 2025-01-01 DOI:10.1016/j.ajur.2024.05.005

Chenkui Miao , Shaobo Zhang , Jiajin Wu , Meiling Bao , Zengjun Wang , Bianjiang Liu

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引用次数: 0

Abstract

Objective

Seminal vesiculitis is a prevalent infectious disease in the genitourinary system, but its intrinsic pathogenesis and molecular features remain unclear.

Methods

In this study, we utilized a next-generation sequencing technology to demonstrate transcriptomic landscapes of clinical specimens from seminal vesiculitis patients. We identified enriched Go Ontology terms, pathway maps, processes, toxicity, and metabolic networks of seminal vesiculitis.

Results

Glutathione S-transferase activity is highly enriched, indicating its essential role in the disease's development. Furthermore, we established inflammation models of the seminal vesicle and verified the crucial function of glutathione S-transferase activity in these models.

Conclusion

Glutathione S-transferase serves an essential role in seminal vesiculitis patients. Our results shall provide a robust platform for further intensive studies of seminal vesiculitis.

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精囊炎转录组图谱绘制及实验验证

目的精囊炎是泌尿生殖系统常见的感染性疾病，但其内在发病机制和分子特征尚不清楚。方法在本研究中，我们利用新一代测序技术来展示精囊炎患者临床标本的转录组景观。我们确定了精囊炎丰富的Go本体术语、途径图、过程、毒性和代谢网络。结果谷胱甘肽s -转移酶活性高，表明其在该病的发生发展中起重要作用。此外，我们建立了精囊炎症模型，并在这些模型中验证了谷胱甘肽s转移酶活性的关键功能。结论谷胱甘肽s -转移酶在精囊炎中起重要作用。我们的研究结果将为精囊炎的进一步深入研究提供一个强有力的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

4.00

自引率

3.80%

发文量

100

审稿时长

4 weeks

期刊介绍： Asian Journal of Urology (AJUR), launched in October 2014, is an international peer-reviewed Open Access journal jointly founded by Shanghai Association for Science and Technology (SAST) and Second Military Medical University (SMMU). AJUR aims to build a communication platform for international researchers to effectively share scholarly achievements. It focuses on all specialties of urology both scientifically and clinically, with article types widely covering editorials, opinions, perspectives, reviews and mini-reviews, original articles, cases reports, rapid communications, and letters, etc. Fields of particular interest to the journal including, but not limited to: • Surgical oncology • Endourology • Calculi • Female urology • Erectile dysfunction • Infertility • Pediatric urology • Renal transplantation • Reconstructive surgery • Radiology • Pathology • Neurourology.