Synthesis, characterization, and antimicrobial activity of some benzimidazolyl, benzoxazolyl, benzothiazolyl-methylsulfanyl-4-aryl-1,4-dihydropyrimidine-5-carbonitrile derivatives

Abstract

We synthetized some methylsulfanyl-4-aryl-1,4-dihydropyrimidine-5-carbonitriles derivatives coupled with benzimidazole, benzoxazole, and benzothiazole rings. Some of these compounds exhibit antibacterial activity, particularly against gram-positive bacteria such as Enterococcus faecalis (6e) and Staphylococcus aureus (4f, 6b, 6i, and 8a).