Primary cutaneous neuroendocrine neoplasms: understanding concepts and approaching the differential diagnosis

Maged Daruish, Gerardo Cazzato, Keisuke Goto, Thibault Kervarrec, Saleem Taibjee
{"title":"Primary cutaneous neuroendocrine neoplasms: understanding concepts and approaching the differential diagnosis","authors":"Maged Daruish,&nbsp;Gerardo Cazzato,&nbsp;Keisuke Goto,&nbsp;Thibault Kervarrec,&nbsp;Saleem Taibjee","doi":"10.1016/j.mpdhp.2024.11.004","DOIUrl":null,"url":null,"abstract":"<div><div>Cutaneous tumours with neuroendocrine differentiation are not uncommon. Many of these tumours share similar clinical, cytological and immunohistochemical features rendering the final diagnosis challenging. Furthermore, some cutaneous tumours may rarely show aberrant expression of neuroendocrine markers, while true neuroendocrine differentiation in these remains debatable. Nomenclature and classification of some entities have also been confusing, reflecting the difficulty in histological interpretation as well as rarity of some of the tumours described, and the evolving understanding of their pathogenesis. For instance, low-grade neuroendocrine carcinoma of the skin has been re-named to sweat gland carcinoma with neuroendocrine differentiation, indicating a likely sweat gland origin. Another example is polymorphous sweat gland carcinoma, of which existence has been debated. In this article, we review the basic histological definitions, discuss incorporating clinicopathological findings and immunohistochemical interpretation when approaching the differential diagnoses of neuroendocrine tumours. We also review the most recently described entities and their evolution in the literature.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"31 2","pages":"Pages 75-86"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Histopathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756231724001877","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Cutaneous tumours with neuroendocrine differentiation are not uncommon. Many of these tumours share similar clinical, cytological and immunohistochemical features rendering the final diagnosis challenging. Furthermore, some cutaneous tumours may rarely show aberrant expression of neuroendocrine markers, while true neuroendocrine differentiation in these remains debatable. Nomenclature and classification of some entities have also been confusing, reflecting the difficulty in histological interpretation as well as rarity of some of the tumours described, and the evolving understanding of their pathogenesis. For instance, low-grade neuroendocrine carcinoma of the skin has been re-named to sweat gland carcinoma with neuroendocrine differentiation, indicating a likely sweat gland origin. Another example is polymorphous sweat gland carcinoma, of which existence has been debated. In this article, we review the basic histological definitions, discuss incorporating clinicopathological findings and immunohistochemical interpretation when approaching the differential diagnoses of neuroendocrine tumours. We also review the most recently described entities and their evolution in the literature.
求助全文
约1分钟内获得全文 求助全文
来源期刊
Diagnostic Histopathology
Diagnostic Histopathology Medicine-Pathology and Forensic Medicine
CiteScore
1.30
自引率
0.00%
发文量
64
期刊介绍: This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信