Nodular Melanoma.

Abstract

Nodular melanoma (NM) is the second most common subtype of cutaneous melanoma (CM), accounting for a substantial proportion of melanoma fatalities. We assessed reviews, cross-sectional evaluations, published guidelines, and clinical reports to summarize the epidemiology, risk factors, clinical presentation, histopathology, molecular attributes, and treatment pearls for NM. Briefly, the incidence of NM and severity at diagnosis remain unchanged over recent decades, underscoring key diagnostic challenges driven by its rapid growth rate and sometimes unremarkable clinical presentation. Dermatoscopy and histopathology remain critical tools in diagnosing NM and may be supplemented with non-invasive imaging techniques such as reflectance confocal microscopy. Societal published guidelines do offer differing management recommendations based on CM subtype; yet, the often thicker and higher stage of NM at diagnosis has important implications for biopsy technique, utility of gene expression profiling, early collaboration with medical and surgical oncology colleagues, and initiation of systemic immunotherapies.