Useful Bowel Preparation with Ultralow-Volume (500 mL) Polyethylene Glycol for Colonoscopy: A Retrospective Study.

IF 2.1 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Digestive Diseases Pub Date : 2025-01-01 Epub Date: 2025-02-03 DOI:10.1159/000543858

Yusuke Mizuno, Takaya Shimura, Takayuki Nukui, Konomu Uno, Ruriko Nishigaki, Yuki Kojima, Takuya Kanno, Makiko Sasaki, Shigeki Fukusada, Naomi Sugimura, Mamoru Tanaka, Keiji Ozeki, Eiji Kubota, Hiromi Kataoka

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引用次数: 0

Abstract

Introduction: Adequate bowel preparation is indispensable for high-quality colonoscopy. We have developed an ultralow-volume (500 mL) polyethylene glycol (PEG) combined with other laxatives (sennoside, sodium picosulfate, and lactulose) and applied this regimen clinically to all patients with colonoscopy for 3 decades. This study aimed to assess the effectiveness of this ultralow-volume bowel preparation regimen.

Methods: This single-center, retrospective study analyzed data from consecutive outpatients who underwent colonoscopy between January 2022 and December 2022. All the patients took sennoside (24 mg) two nights before, sodium picosulfate (75 mg) one night before, and 500 mL of PEG with lactulose (58.5 g) on the day of examination. Cleaning efficacy was evaluated using the Boston Bowel Preparation Scale (BBPS). Adequate bowel preparation was defined as a total BBPS score ≥6, with all colon segments scoring ≥2.

Results: Out of 862 patients with colonoscopy, 773 were eligible for this study, and the median age was 66 years. The adequate bowel preparation rate was 91.8% (710/773). Notably, the BBPS full score "9" was observed in 50.5% (390/773). The median cecal intubation time and examination time were 8 and 20 min, respectively. Only 3 patients vomited as a side effect. In the multivariate analysis, age ≥70 years, diabetes mellitus, and diverticula were significantly independent risk factors for inadequate bowel preparation.

Conclusions: Our established ultralow-volume (500 mL) PEG is safe and useful as a bowel preparation method.

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用超低容量（500毫升）聚乙二醇进行结肠镜检查的有益肠道准备：一项回顾性研究。

充分的肠道准备是高质量结肠镜检查必不可少的。我们开发了一种超低容量（500毫升）聚乙二醇（PEG）与其他泻药（sennoside， picosulfate钠和乳果糖）联合使用，并将该方案临床应用于所有结肠镜检查患者30年。本研究旨在评估这种超低容量肠道准备方案的有效性。方法：这项单中心回顾性研究分析了2022年1月至2022年12月期间连续接受结肠镜检查的门诊患者的数据。所有患者在检查前2晚服用sennoside (24 mg)，在检查前1晚服用picosulfate钠（75 mg），检查当天服用PEG加乳果糖（58.5 g） 500 ml。使用波士顿肠道准备量表（BBPS）评估清洁效果。充分的肠道准备被定义为总BBPS评分≥6，所有结肠段评分≥2。结果：在862例结肠镜检查患者中，773例符合本研究条件，中位年龄为66岁。肠道准备充分率为91.8%（710/773）。值得注意的是，50.5%（390/773）的BBPS满分为“9”。盲肠插管中位时间为8 min，检查时间为20 min。只有3名患者出现了呕吐的副作用。在多因素分析中，年龄≥70岁、糖尿病和憩室是肠准备不充分的独立危险因素。结论：我们建立的超低容量（500ml） PEG作为肠道准备方法是安全有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Diseases 医学-胃肠肝病学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Each issue of this journal is dedicated to a special topic of current interest, covering both clinical and basic science topics in gastrointestinal function and disorders. The contents of each issue are comprehensive and reflect the state of the art, featuring editorials, reviews, mini reviews and original papers. These individual contributions encompass a variety of disciplines including all fields of gastroenterology. ''Digestive Diseases'' bridges the communication gap between advances made in the academic setting and their application in patient care. The journal is a valuable service for clinicians, specialists and physicians-in-training.