Recent Advances for Synthesis of Benzothiazoles from Arylmethylamines

Abstract

The benzofused N,S‐containing benzothiazole heterocycles and their scaffolds have remarkable biological and pharmaceutical applications. Attentively, the development towards structurally diverse benzothiazoles via C(sp³)−H functionalization of arylmethylamines has been the main attraction for synthetic organic chemists. In this review, the various synthetic approaches from C−H/C−N bond functionalization of arylmethylamines/amines as a new emerging substrate are described in detail towards the synthesis of substituted benzothiazoles. Furthermore, it gives insights into substrate scope and the reaction mechanistic pathway for the formation of final targeted benzothiazole products.