Bioreactor Engineering for Circular Economy: Bioactive Compound Production in Solid-State Fermentation—Review

IF 1.8 4区工程技术 Q3 ENGINEERING, CHEMICAL

Chemical Engineering & Technology Pub Date : 2024-11-14 DOI:10.1002/ceat.202400289

Dr. Gerardo A. Gómez-Ramos, Dr. Lilia A. Prado-Barragán, Brianda A. Rivera, Dr. Sergio Huerta-Ochoa, Dr. Víctor M. Rivera, Dr. Moises Couder-García, Dr. Rocío de los Ángeles García-Hernández, Dr. Carlos O. Castillo-Araiza

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Abstract

Solid-state fermentation (SSF) has gained considerable attention due to its potential in the production of bioactive compounds from agroindustrial residues, aligning with circular economy targets. This review examines the core bases involved in SSF with a focus on bioreactor engineering. The review underlines the microorganisms metabolic activities under different operational conditions and focuses on engineering challenges encountered in designing packed-bed bioreactors, including an analysis of the interaction between microbial growth kinetics and transport phenomena. Finally, given its essential role in the scaling-up process, this review discusses mathematical modeling developed for SSF in packed-bed bioreactors, establishing a foundation for the future development of more efficient, scalable, and sustainable SSF-based applications.

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面向循环经济的生物反应器工程：固态发酵生产生物活性化合物综述

固态发酵（SSF）由于其在从农业工业残留物中生产生物活性化合物方面的潜力而获得了相当大的关注，符合循环经济的目标。本文以生物反应器工程为重点，综述了生物反应器工程中涉及的核心基础。这篇综述强调了微生物在不同操作条件下的代谢活动，并重点介绍了设计填料床生物反应器时遇到的工程挑战，包括微生物生长动力学和运输现象之间的相互作用的分析。最后，鉴于其在放大过程中的重要作用，本文讨论了填料床生物反应器中SSF的数学模型，为未来开发更高效、可扩展和可持续的SSF应用奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Engineering & Technology 工程技术-工程：化工

CiteScore

3.80

自引率

4.80%

发文量

315

审稿时长

5.5 months

期刊介绍： This is the journal for chemical engineers looking for first-hand information in all areas of chemical and process engineering. Chemical Engineering & Technology is: Competent with contributions written and refereed by outstanding professionals from around the world. Essential because it is an international forum for the exchange of ideas and experiences. Topical because its articles treat the very latest developments in the field.