Robust G-Quadruplex Dimer-Guided Transmembrane DNA Nanovehicles for Targeted Payload Delivery

Abstract

Here we report a robust G-quadruplex (G4) dimer-guided transmembrane DNA nanovehicle for targeted payload delivery, based on dimeric G4-proximized aptamers that efficiently target transferrin receptors (TfR) over-expressed on cancer cell surface. It enables the cancer-specific delivery of fluorescent G4 ligands and therapeutic drugs for cellular imaging and treatment.