Fluorescence imaging-guided lipid droplets-localized photodynamic therapy

IF 13.9 Q1 CHEMISTRY, MULTIDISCIPLINARY

Aggregate (Hoboken, N.J.) Pub Date : 2024-10-01 DOI:10.1002/agt2.665

Shan Wang, Qiang Wang, Yang Lv, Zhe Liu, Kippeum Lee, Dongeun Kim, Miae Won, Jianliang Shen, Jong Seung Kim

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Abstract

Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment due to its non-invasive nature and high specificity toward malignant tissues. In recent years, a variety of protocols have been proposed to improve the PDT efficacy, of which organelle-targeted PDT strategy is supposed to be quite promising. Particularly, lipid droplets (LDs)-localized PDT attracts a lot of interest due to the inherent advantages such as abundant LDs in cancer cells and their close relation with ferroptosis. This review provides a comprehensive summary of the advancements of LDs-localized photosensitizers (PSs) according to their chemical structures and functions. Especially, these PSs are featured with fluorescence emission, thereby facilitating an imaging-guided phototherapy. The review highlights the cytocidal actions of these PSs, such as the cell death pathway and their cytotoxicity. Finally, some unresolved issues and challenges in this domain will be discussed.

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荧光成像引导脂滴定位光动力治疗

光动力疗法（PDT）因其非侵入性和对恶性组织的高特异性而成为一种很有前途的癌症治疗策略。近年来，人们提出了多种方案来提高PDT的疗效，其中细胞器靶向PDT策略被认为是很有前途的。特别是脂滴定位PDT，由于其固有的优势，如癌细胞中丰富的脂滴及其与铁下垂密切相关，引起了人们的广泛关注。本文从化学结构和功能等方面综述了lds定位光敏剂的研究进展。特别是，这些ps具有荧光发射的特点，从而促进了成像引导的光疗。本文综述了这些ps的细胞杀伤作用，如细胞死亡途径及其细胞毒性。最后，讨论了该领域尚未解决的问题和挑战。

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