Synthesis of 5,6-Dialkyl-4-aryl-2-aminopyridine-3-carbonitriles and In Vitro Study of Their Antimicrobial Activity

Abstract

A three-component reaction for the synthesis of highly functionalized pyridine derivatives was studied. The cyclization reaction patterns were investigated, and it was shown that in the case of using methyl ethyl ketone and methyl isobutyl ketone, the methylene group participates in the condensation reaction. The biological activity of the obtained compounds against the Staphylococcus aureus and Pseudomonas aeruginosa bacteria, as well as Candida utilis yeast-like fungi was studied, and compounds with high antibacterial activity were revealed.