TUBB3 Expression in Nonsmall Cell Lung Cancer Tissue: Reasons for Immunohistochemical Assay Discordance and an Approach to Overcome It

IF 0.5 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2025-01-27 DOI:10.3103/S0027131424700457

T. A. Bogush, A. Lee, S. A. Kalyuzhny, E. A. Bogush, M. Ya. Melnikov, V. S. Kosorukov

引用次数: 0

Abstract

The reasons for discordance data on the contribution of a TUBB3 microtubule protein to resistance to antitumor drugs and the metastatic potential of tumors with an assessment of prognostic significance of TUBB3 expression in nonsmall cell lung cancer tissue are analyzed. The need to introduce quantitative analysis methods in molecular diagnostics of tumors (in particular, immunofluorescence assessment associated with flow cytometry) is substantiated.

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TUBB3在非小细胞肺癌组织中的表达：免疫组化检测不一致的原因及克服方法

分析了TUBB3微管蛋白对抗肿瘤药物耐药和肿瘤转移潜力的贡献与评估TUBB3在非小细胞肺癌组织中表达的预后意义数据不一致的原因。在肿瘤分子诊断中引入定量分析方法（特别是与流式细胞术相关的免疫荧光评估）的必要性得到证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.