S. Bai, M. Zhang, M. Li, S. Wan, F. Wang, S. Tang, X. Wei, S. Feng, R. Wu
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引用次数: 0
Abstract
A series of novel coumarin derivatives was successfully synthesized by combining the coumarin skeleton with a benzylamine moiety. These derivatives showed better antibacterial activities in vitro tests, especially compound, which was particularly effective. The mechanism of the antibacterial action of compound was thoroughly investigated, and the experimental results revealed that compound was able to increase the permeability of bacterial cell membranes, leading to the disruption of Xoc membranes and effectively inhibiting bacterial growth and reproduction. This finding not only elucidates the antibacterial mechanism of compound, but also provides an important scientific basis for the development of new antibacterial agents in the future.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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