Synthesis, Characterization, and Biological Evaluation for New Derivatives Based on 2Сhloro-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]acetamide

Abstract

A new compound, 2-chloro-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]acetamide, was obtained using a multi-step reaction and converted into the corresponding aldehyde. The latter was used for the synthesis of new Schiff bases derivatives. These compounds were characterized via physical and spectral data (IR, ¹H NMR) besides to CHN analysis of some of them and biological activity. Such types of activities as enzyme inhibition, antimicrobial and antifungal activity were studied.