Synthesis, Structure, and Biological Activity of Mixed-Ligand Copper(II) Coordination Compounds with 2-(3,5-Dibromo-2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide Containing Certain N-Heteroaromatic Bases

Abstract

Сopper(II) nitrate and acetate have reacted in ethanol with 2-(3,5-dibromo-2-hydroxybenzyliden)-N-(prop-2-en-1-yl)hydrazinecarbothioamide (H₂L) in a 1 : 1 molar ratio with the formation of the [Cu(L)(H₂O)] and [Cu(Н₂О)(НL)]₂(NO₃)₂^.EtOH^.H₂O complexes, respectively. Their reactions with ethanolic solution of N-heteroaromatic amines (1,10-phenanthroline (1,10-Phen), 2,2′-bipyridyl (2,2′-Bpy), and 3,4-dimethylpyridine (3,4-Lut)) in a 1 : 1 molar ratio have yielded the [Cu(A)(L)] and [Cu(A)(HL)]NO₃ complexes (A = 1,10-Phen; 2,2′-Bpy; 3,4-Lut). The structure of two copper(II) complexes has been established by X-ray diffraction analysis. The obtained complexes have exhibited antimicrobial, antifungal, and antioxidant activities.