Synthesis and Analgesic Activity of Substituted N-Alkyl-4-aryl-2-aroylhydrazylidene-4-oxobutanamides

Abstract

A series of new substituted derivatives of N-alkyl-4-aryl-2-aroylhydrazylidene-4-oxobutanamides were synthesized via the opening of the furan ring in substituted 3-N-5-aryl-2-oxofuran-3(2H)-ylidene-4-R¹-benzohydrazides under the action of various alkylamines. The in vivo analgesic activity and acute toxicity of the synthesized compounds were assessed to show that they have a pronounced analgesic activity and are almost nontoxic.