Platelet proteomics: An analytical perspective with reference to tuberculosis

Abstract

Tuberculosis has been a continual threat for generations and is still at large amidst the global population. Disease detection is crucial in early diagnosis for premature treatment. Analytical techniques have come handy with respect to detection of tuberculosis in various biological fluids in diseased humans. Blood, serum, urine, sputum-based proteomics has been used for the analytical detection of tuberculosis biomarkers. This review has summarized the platelet proteomics based detection of tuberculosis and the classical and state-of-the-art analytical techniques that are in the game with respect to tuberculosis disease diagnosis. The isolation methods and pre analytical preparative methods and analytical techniques for platelet proteomics for tuberculosis detection have been presented. The challenges and the future perspective of platelet proteomics for tuberculosis disease detection have been highlighted. This is the first review of this kind in this subject area.