The beneficial effects of the herbal medicine Di-Huang-Yin-Zi on patients with traumatic cauda equina injury: A randomized, double-blind, placebo-controlled study

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE

Explore-The Journal of Science and Healing Pub Date : 2025-01-30 DOI:10.1016/j.explore.2025.103134

Mei Yu , Pi-Zhen Zu , Li-Yang Guo , Qing-Hua Zhang , Lian-Tao Li

{"title":"The beneficial effects of the herbal medicine Di-Huang-Yin-Zi on patients with traumatic cauda equina injury: A randomized, double-blind, placebo-controlled study","authors":"Mei Yu , Pi-Zhen Zu , Li-Yang Guo , Qing-Hua Zhang , Lian-Tao Li","doi":"10.1016/j.explore.2025.103134","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the safety and efficacy of Di-Huang-Yin-Zi (DHYZ), also known as Rehmanniae Yin-Zi, a traditional Chinese medicinal formula used for treating of neurological disorders in patients with traumatic cauda equina injury (TCEI).</div></div><div><h3>Methods</h3><div>In this double-blind, placebo-controlled study, TCEI patients with American Spinal Injury Association (ASIA) impairment grades C were randomized to receive either DHYZ (<em>n</em> = 30) or placebo (<em>n</em> = 30) for 8 weeks. Both groups also received rehabilitation therapy and oral mecobalamine therapy during the treatment. Motor and sensory functions, as well as walking ability, were assessed biweekly.</div></div><div><h3>Results</h3><div>At the end of the treatment, the DHYZ group exhibited significantly higher scores in sensory and motor function, as well as walking ability, compared to the placebo group (all <em>P</em> < 0.05). Additionally, no serious side effects were reported.</div></div><div><h3>Conclusion</h3><div>DHYZ has the potential to accelerate nerve repair and may serve as an effective adjuvant therapy to enhance the recovery of nerve function in patients with TCEI.</div></div>","PeriodicalId":50459,"journal":{"name":"Explore-The Journal of Science and Healing","volume":"21 2","pages":"Article 103134"},"PeriodicalIF":1.9000,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Explore-The Journal of Science and Healing","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1550830725000254","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This study aimed to investigate the safety and efficacy of Di-Huang-Yin-Zi (DHYZ), also known as Rehmanniae Yin-Zi, a traditional Chinese medicinal formula used for treating of neurological disorders in patients with traumatic cauda equina injury (TCEI).

Methods

In this double-blind, placebo-controlled study, TCEI patients with American Spinal Injury Association (ASIA) impairment grades C were randomized to receive either DHYZ (n = 30) or placebo (n = 30) for 8 weeks. Both groups also received rehabilitation therapy and oral mecobalamine therapy during the treatment. Motor and sensory functions, as well as walking ability, were assessed biweekly.

Results

At the end of the treatment, the DHYZ group exhibited significantly higher scores in sensory and motor function, as well as walking ability, compared to the placebo group (all P < 0.05). Additionally, no serious side effects were reported.

Conclusion

DHYZ has the potential to accelerate nerve repair and may serve as an effective adjuvant therapy to enhance the recovery of nerve function in patients with TCEI.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Explore-The Journal of Science and Healing 医学-全科医学与补充医学

CiteScore

3.00

自引率

8.30%

发文量

179

审稿时长

25 days

期刊介绍： EXPLORE: The Journal of Science & Healing addresses the scientific principles behind, and applications of, evidence-based healing practices from a wide variety of sources, including conventional, alternative, and cross-cultural medicine. It is an interdisciplinary journal that explores the healing arts, consciousness, spirituality, eco-environmental issues, and basic science as all these fields relate to health.