Immune Cells as Trojan Horses for Cancer Nanotherapy

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2024-12-08 DOI:10.1021/acsmaterialslett.4c0152310.1021/acsmaterialslett.4c01523

Cristina Hermosillo-Abundis, Jessica Andrea Flood-Garibay, Vanesa Ayala-Nunez* and Miguel Angel Méndez-Rojas*,

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引用次数: 0

Abstract

Nanotechnology is a promising strategy in the fight against cancer by leveraging the unique properties of nanomaterials for targeted drug delivery. A significant challenge in this domain is overcoming biological barriers and ensuring precise delivery to tumor sites. Immune cells, inherently adept at navigating the body’s defense systems and homing to tumor sites, present an excellent solution as Trojan horses for cancer nanotherapy. This review explores the utilization of immune cells as carriers or mediators of nanoparticle-based therapeutics. The Trojan horse strategy is presented in the context of nanomedicine and cancer, followed by a discussion of its advantages. Next, the diversity of nanoparticle systems that have shown positive therapeutic outcomes in preclinical studies is explored. The challenges of using immune cells as Trojan horses, such as nanoparticle loading and manipulation, are analyzed. Finally, strategies for fine-tuning nanoparticles to design an effective Trojan horse approach are suggested. By synthesizing current research findings, this review underscores the potential of nanotechnology in combination with immune cells for innovative and effective cancer treatments.

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.